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61.
62.
Brusov V. S. Korchagin P. O. Malyshev V. V. Piyavsky S. A. 《Journal of Computer and Systems Sciences International》2020,59(1):83-94
Journal of Computer and Systems Sciences International - The article considers the problem of making multicriteria decisions in which the decision maker (DM) has the opportunity to indicate the... 相似文献
63.
64.
Lisichkin S. E. Rubin O. D. Pashchenko F. A. 《Power Technology and Engineering (formerly Hydrotechnical Construction)》2021,55(3):373-379
Power Technology and Engineering - The experimental results on retaining reinforced-concrete walls reinforced with anchor ties and carbon composite materials on the face side of hydraulic... 相似文献
65.
Metallurgist - D-403 weakly basic anion exchange resin is used for the sorption extraction of gallium in the form of hydroxo complexes from alkaline aluminate solutions. The thermodynamic... 相似文献
66.
Firstov S.A. Gorban V. F. Karpets M. V. Krapivka M. O. Rokytska O. A. Samelyuk A. V. 《Powder Metallurgy and Metal Ceramics》2019,57(11-12):731-739
Powder Metallurgy and Metal Ceramics - The microstructure, phase composition, and mechanical properties of Ti–Cr–Al–Si–O alloys in ascast state and after annealing at... 相似文献
67.
Dr. Ivan A. Yaremenko Dr. Paolo Coghi Parichat Prommana Congling Qiu Peter S. Radulov Yuanqing Qu Yulia Yu. Belyakova Dr. Enrico Zanforlin Dr. Vladimir A. Kokorekin Yuki Yu Jun Wu Prof. Fabrice Fleury Dr. Chairat Uthaipibull Dr. Vincent Kam Wai Wong Prof. Alexander O. Terent'ev 《ChemMedChem》2020,15(13):1118-1127
This article discloses a new horizon for the application of peroxides in medical chemistry. Stable cyclic peroxides are demonstrated to have cytotoxic activity against cancer cells; in addition a mechanism of cytotoxic action is proposed. Synthetic bridged 1,2,4,5-tetraoxanes and ozonides were effective against HepG2 cancer cells and some ozonides selectively targeted liver cancer cells (the selectivity indexes for compounds 11 b and 12 a are 8 and 5, respectively). In some cases, tetraoxanes and ozonides were more selective than paclitaxel, artemisinin, and artesunic acid. Annexin V flow-cytometry analysis revealed that the active ozonides 22 a and 23 a induced cell death of HepG2 by apoptosis. Further study showed that compounds 22 a and 23 a exhibited a strong inhibitory effect on P-glycoprotein (P-gp/ABCB5)-overexpressing HepG2 cancer cells. ABCB5 is a key player in the multidrug-resistant phenotype of liver cancer. Peroxides failed to demonstrate a direct correlation between oxidative potential and their biological activity. To our knowledge this is the first time that peroxide diastereoisomers have been found to show stereospecific antimalarial action against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Stereoisomeric ozonide 12 b is 11 times more active than stereoisomeric ozonide 12 a (IC50=5.81 vs 65.18 μm ). Current findings mean that ozonides merit further investigation as potential therapeutic agents for drug-resistant hepatocellular carcinoma. 相似文献
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Advanced technologies and modern high-production machines for underground mining of thick gently dipping coal demand strict adherence to technological discipline, reduction in operational loss and selection of optimized ventilation modes. The authors analyze ventilation schemes used in working areas in thick gently dipping seams in order to reveal influence exerted by the schemes, methods and parameters of ventilation on distribution of air loss in mined-out areas. 相似文献
70.
Technical Physics Letters - Using the method of DC magnetron sputtering, nonstructured amorphous metal coatings of Zr75Pd25 composition were obtained with an average deposition rate of 1.3 nm/s at... 相似文献